Making cancer treatment more bearable with AgainLife medical devices Skin and mucosal protection during cancer treatment

again-life-italia-logoThis is what to expect from AgainLife medical devices when it comes to minimising or even preventing the side effects of chemotherapy or radiotherapy. The proven and patented active substance adelmidrol is what makes the AgainLife range so remarkable – products that are now available to pharmacies from Bendalis GmbH in Oberhaching.

Adelmidrol is a palmitoylethanolamide analogue developed specially for use in cancer therapy by Italian oncologist and specialist in internal medicine, Dr Raffaele Migliaccio, which has already been tested in numerous studies throughout Europe. This fatty acid molecule occurs naturally in the cells of the body. It accumulates at the mastocyte receptors and thus regulates excessive mastocyte activity along with the increased release of neurotransmitters.

In cancer patients in particular, who are exposed to particular stress due to chemotherapy or radiotherapy, the activity of the mastocytes in the skin and mucous membranes is intensified. Neurotransmitters are thereby released and the mastocytes subjected to permanent stress – resulting in damage to the skin and pain.

Since endogenous palmitoylethanolamide is broken down very rapidly on an intracellular level, an imbalance therefore results during chemotherapy and radiotherapy. This lack of a balanced immune response can be effectively counteracted with adelmidrol. Treatment-induced damage in healthy cells with high rates of division, such as the cells of the skin, hair, blood and intestine, can be kept as low as possible.

The adelmidrol concentration and formulation vary in the AgainLife medical devices products available from pharmacies, thus permitting a wide range of uses for skin and mucosal problems, as can occur during cancer treatment. The products are available as skin creams and milks, vaginal gel, urinary catheter gel, mouthwash or spray, hair lotion, and anal cream. Depending on the indication and formulation, the products contain added ingredients such as dodecanoic, thioctic and lipoic acid, as well as hyaluronic acid, phytosphingosines or the analgesic capsaicin.